Study Of Anxiolytic Activity Of Azadirachta Indica Leaves In Albino Rats

Abstract

Background: Azadirachta indica or Neem of Meliaceae family is a rich source of antioxidant. Azadirachta indica is regarded as a health-promoting medicine and used in various forms globally. It is lengthily used in Indian Subcontinent province for the treatment and prevention of an assortment of ailments. Objective: The objective of this study is to observe the anxiolytic action of methanol extract of Azadirachta indica.

Materials and methods:  Methanolic extract of Azadirachta indica (MEAI) was administered in the doses of 100, 300 and 600 mg/kg p.o. For determination of anxiolytic activity, hole board (HB), open field (OF), elevated plus maze (EPM) and light/dark exploration (LDE) tests were used.

Results: The period and quantity of the poking of the head in HB test was amplified by the methanolic extract of Azadirachta indica  in a substantial manner. The total exhausted duration was augmented by the extract in EPM.  The extract created a remarkable boost in the total exhausted timing in LDE test. Also, it augmented the number of crossings and lessend the total period of the indolence in light box. The extract displayed significant boost in the the total number of rearing and assisted rearing in OFT.

Conclusion: This work exhibits EAAI anxiolytic action which might be credited to its ‘phyto-constituents’ viz. ‘alkaloid’, ‘steroid’ and ‘triterpenes’. This is possibly a moderately reasonable therapeutic agent for the cure of anxiety dysfunction, since Azadirachta indica is ubiquitous and abundantly grown.