Demonstrating Mechanisms Of Ischemic Postconditioning
The potential mechanisms of ischemia postconditioning, the presence of comorbidities, and the prospective extrapolation to the clinical situation are reviewed. In the near future, large, multicentered, randomized, placebo-controlled, clinical trials will be necessary to evaluate if pharmacological and/or ischemic postconditioning can enhance the clinical out- comes of patients with IHD. This study reviews publications on the subject of ischemia postconditioning of the heart. The study demonstrates that postconditioning clinical trials using this approach in the context of predicted ischemia-reperfusion have achieved encouraging results, and other investigations to characterize the potential clinical utility of these tactics are ongoing.